What is THCV? 5 Things to Know About THCV

Jun 9, 2022

5 Things to Know About Tetrahydrocannabivarin (THCV)

1. THCV is non-intoxicating

Don’t be fooled by the similar name to its cousin THC. Unlike THC which has intoxicating and euphoric effects, THCV is non-intoxicating.

2. THCV is a rare cannabinoid

While THC is found abundantly in many strains of the Cannabis plant, THCV is a rare cannabinoid that is generally found in only trace amounts in the plant.

3. THCV interacts with several cannabinoid receptors

Scientific literature suggests that THCV acts as an antagonist of cannabinoid receptor 1 (CB1), TRPV5 and TRPV6, as an agonist of cannabinoid receptor 2 (CB2), TRPV1, GPR55 and TRPA1, and inhibits 2-AG production.

4. ∆9-THCV has been studied for its appetite suppression effects

∆9-THCV is one the most well-researched rare cannabinoids showing effects in a myriad of conditions. THCV has been researched extensively for its appetite suppression effects that are attributed to THCV’s interaction with specific receptors involved with rewarding stimuli.

5. There are two known variants of THCV

∆9-THCV (d9-THCV) is the naturally-occurring variant found in the Cannabis plant and has been the subject of the vast majority of scientific research into the potential effects of THCV. Both∆8-THCV (d8-THCV) and ∆9-THCV have been manufactured, however ∆9-THCV is much more difficult to synthesize.

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